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facilities and Prof. Laurence Eaves for a helpful review of the manuscript. Last but not least, we want to dedicate this paper to the memory of our colleague and friend Roberto Marco, on the fifth anniversary of his passing away last 27 June 2008, whose mentorship was crucial to allow this research to be completed."},{"name":"DOI","value":"10.26030/syws-9962"},{"name":"Data Source Accession","value":"GSE33779"},{"name":"Data Source Link","value":"http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE33779"},{"name":"Experiment Platform","value":""},{"name":"Flight Program","value":""},{"name":"Funding","value":"This work was supported by grants from the Spanish Space Program in the Plan Nacional de Investigacion Cientifica y Desarrollo Tecnologico and MICINN; the Dutch NWO-ALW-SRON grant and the UK Engineering and Physical Sciences Research Council (EPSRC), Basic Technology grants. Access to GBFs was granted by ESA. R. Herranz was supported by Spanish Ministerio de Educacion y Ciencia International Research Centers fellowships program in ESTEC and by the Consejo Superior de Investigaciones Cientificas CSIC JAE-Doc contract. RJAH acknowledges EPSRC for support under a Research Fellowship."},{"name":"Identifiers","value":""},{"name":"Managing NASA Center","value":""},{"name":"Mission End","value":""},{"name":"Mission Link","value":""},{"name":"Mission Name","value":""},{"name":"Mission Start","value":""},{"name":"Project Identifier","value":"Simulated_Hypergravity, Simulated_Microgravity, Simulated_Environmental_Factors"},{"name":"Project Link","value":""},{"name":"Project Title","value":""},{"name":"Project Type","value":"Ground Study"},{"name":"Space Program","value":""},{"name":"Study Grant Number","value":"This work was supported by grants from the Spanish Space Program in the Plan Nacional de Investigacion Cientifica y Desarrollo Tecnologico [ESP2006-13600-C02-01] and MICINN [AYA2009-07792-E]; the Dutch NWO-ALW-SRON grant [MG-057] and the UK Engineering and Physical Sciences Research Council (EPSRC), Basic Technology grants [GR/S83005/01 and EP/G037647/1]. Access to GBFs was granted by ESA contract number 4200022650. R. Herranz was supported by Spanish Ministerio de Educacion y Ciencia International Research Centers fellowships program in ESTEC and by the Consejo Superior de Investigaciones Cientificas CSIC JAE-Doc contract. RJAH acknowledges EPSRC for support under a Research Fellowship [EP/I004599/1 and EP/J005452/1]."}],"description":"Genome-wide transcriptional profiling showed that reducing gravity levels in the International Space Station (ISS) causes important alterations in Drosophila gene expression intimately linked to imposed spaceflight-related environmental constrains during Drosophila metamorphosis. However, simulation experiments on ground testing space-related environmental constraints, show differential responses. 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